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Brain Training May Lower Dementia Risk, Landmark Study Finds

A groundbreaking update from a decades-long investigation suggests that specific forms of brain training can significantly reduce the risk of developing dementia in older adults.

The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study, which began in the late 1990s, has revealed that participants who received cognitive speed training were 25% less likely to be diagnosed with dementia over a 20-year period compared to those who did not receive the training.

Nearly 3,000 adults, aged 65 to 94 at the start of the trial, participated in the study. Researchers randomly assigned participants to four groups: memory training, reasoning training, speed of processing training, or a control group that received no training. Those in the training groups underwent ten 60- to 75-minute sessions over six weeks.

A subset of participants also received “booster” training sessions at 11 months and 35 months after the initial sessions. According to researchers at the University of Florida College of Public Health and Health Professions, participants who underwent a maximum of 18 training sessions over three years showed the greatest benefits.

“Our initial findings had shown benefits of several training arms up to 10 years after training, with participants reporting less impairment in tasks of daily living and fewer motor vehicle crashes,” said Michael Marsiske, PhD, a professor and interim co-chair of the Department of Clinical and Health Psychology at UF Health. “These 20-year findings strongly suggest that engagement in cognitive training does no harm and may confer substantial benefit.”

The speed training component, which showed the most promising results, required participants to process visual information on a computer screen and make quick decisions. As participants improved in speed and accuracy, the training became progressively more difficult. Researchers believe this type of training may cause physical changes to the brain, creating new and stronger connections between neural networks.

The ACTIVE study represents a significant breakthrough in dementia prevention research. According to the investigators, this is one of the first studies to demonstrate that any intervention—whether cognitive training, brain games, physical exercise, diet, or medication—can lower the incidence of Alzheimer’s disease and related dementias.

Five years into the study, participants reported practical benefits in their daily lives, including less difficulty with tasks such as cooking, taking medications, and managing finances. After ten years, those trained in reasoning and speed processing maintained their cognitive improvements.

The findings, published in the journal Alzheimer’s & Dementia: Translational Research and Clinical Interventions, have spurred plans for follow-up trials. Researchers aim to explore how cognitive training might be combined with other lifestyle interventions such as physical activity, dietary improvements, and blood pressure management to enhance brain health in older adults.

“I’m most excited about the ability to merge real-world data, like Medicare records, with a clinical trial like ours,” Marsiske told reporters.

The study was funded by the National Institute on Aging and the National Institute of Nursing Research, highlighting the significant federal investment in finding effective approaches to combat dementia, a condition that affects millions of Americans and costs billions in healthcare expenses annually.

These findings align with other recent research linking certain activities to reduced dementia risk. A study published in JMIR Serious Games found that playing certain smartphone games can improve attention and memory. Dr. Daniel Amen, psychiatrist and founder of Amen Clinics, noted that continuing to learn and challenge the brain is “critical” for cognitive health.

“If you can be disciplined, word games, for example, or Sudoku games… can be helpful and have been shown to increase memory,” Amen said. He recommends spending at least 15 minutes daily learning something new, whether it’s a language, musical instrument, gardening technique, or cooking skill.

As the global population ages, these findings offer promising evidence that relatively simple, accessible interventions could help reduce the burden of dementia and improve quality of life for older adults.

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12 Comments

  1. Patricia Thompson on

    Fascinating study on the long-term benefits of cognitive training in reducing dementia risk. It’s encouraging to see such promising results from this large, rigorous trial. I wonder if the training techniques could be adapted into accessible, affordable programs for the general public.

    • Agreed, this is an important finding that could have a significant public health impact if the training methods can be widely implemented. The 25% reduction in dementia risk is quite substantial.

  2. Michael Hernandez on

    While the results are certainly promising, I would caution against over-interpreting the findings at this stage. Large, longitudinal studies like this can be complex, and the true long-term effects may take additional time and research to fully elucidate. Still, the potential to meaningfully reduce dementia risk is exciting and warrants further investigation.

    • Olivia J. Rodriguez on

      That’s a fair assessment. Maintaining a degree of cautious skepticism is prudent when evaluating novel therapeutic approaches, especially those with such profound potential implications. Rigorous follow-up studies will be crucial to validate and expand on these initial findings.

  3. This is really promising research on the potential for cognitive training to stave off dementia. I’d be curious to learn more about the specific exercises and approaches used in the speed of processing training that yielded the best results. Identifying effective, scalable brain fitness programs could be transformative.

    • Yes, the details on the training regimen would be valuable to understand. It would be great if this type of intervention could become a routine part of senior care and wellness programs.

  4. Michael Thompson on

    This is a really intriguing and hopeful finding. Dementia is such a devastating condition, so any intervention that can reduce the risk by a quarter is quite remarkable. I’m curious to see if the benefits hold up across different cognitive domains, or if the speed of processing training was uniquely impactful. Either way, this is an important step forward.

    • Agreed, the specifics around which types of cognitive training are most effective will be crucial to understand. Identifying the key mechanisms at play could unlock even more powerful interventions down the line.

  5. As someone with a family history of dementia, I find this research very intriguing. The idea that targeted cognitive exercises could reduce the risk by 25% is quite remarkable. I wonder if the benefits are more pronounced for certain demographics or risk profiles. Definitely an avenue worth further exploration.

    • That’s a great point about looking at the results through different demographic lenses. Understanding which populations benefit most could help tailor and target these types of programs for maximum impact.

  6. As someone who works in the healthcare field, I’m really encouraged by this research. Anything that can help stave off dementia and preserve quality of life for older adults is incredibly valuable. I’m curious to learn more about the cost-effectiveness and scalability of these cognitive training programs. Integrating them into routine care could be transformative.

    • Patricia A. Lopez on

      Excellent point about the potential cost-effectiveness and scalability. If these training methods can be delivered in a financially viable way, it could make a huge difference in communities with limited access to dementia care resources.

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